Sodium Hydroxide → HCID 178465664, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-(4-(trifluoromethoxy)phenyl)thiazole-2-carbohydrazide (10.0 g, 33.0 mmol) in THF (100 mL) were added acetamidine hydrochloride (62 g, 66 mmol) and sodium hydroxide (4 g, 99 mmol). The mixture was stirred at 100° C. for 16 h, and then concentrated under reduced pressure. The white solid residue was washed with H2O (30 mL), filtered and dried to afford the title compound as a white solid (10 g, 88%). MS (ES+) C13H11F3N4O2S requires: 344. found: 345 [M+H]+.

Provenance & Evidence