Cesium carbonate → HCID 86711943, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-bromo-2-methoxyethane (3.2 mg, 0.023 mmol), Cs2CO3 (9.4 mg, 0.029 mmol) and 3-((5-methyl-3-(4-(4-(trifluoromethoxy)phenyl)thiazol-2-yl)-1H-1,2,4-triazol-1-yl)methyl)phenol (5.0 mg, 0.012 mmol; synthesized in analogous manner to Example 59, using 2-(5-methyl-1H-1,2,4-triazol-3-yl)-4-(4-(trifluoromethoxy)phenyl)thiazole, Example 87, Step 4) in DMSO (0.2 ml) was stirred at 50° C. for 20 minutes. The mixture was purified by prep-HPLC to give the title compound; MS (ES+) C23H21F3N4O3S requires: 474. found: 475 [M+H]+.

Provenance & Evidence