Methanol → HCID 83853109, compound

Participants

Reaction Conditions

Reaction Steps

A solution of borane-dimethyl sulfide complex in THF (2 M, 3.75 mL) was added to 6′ chloro-spiro[cyclopentane-1,3′-[3H]indol]-2′(1′H)-one under nitrogen and the resulting solution stirred at 20° C. for 0.2 h then at reflux for 1 h. The mixture was cooled then MeOH (3 mL) was added slowly (caution,) and reflux resumed for 1 h. Excess solvent was evaporated in vacuo and chromatography of the residue (SiO2; gradient elution with 0-40% Et2O in petrol) gave the title compound (0.335 g, 88%). MS: [M+H]+=208.

Provenance & Evidence