反应详情

To a solution of 5-bromo-3,3-dimethyl-2,3-dihydro-1H-indole (1.6 g, 7.1 mmol) in DCM (40 mL) and pyridine (1.1 mL, 14.2 mmol) was added acetic anhydride (1 mL, 11 mmol). The reaction was stirred at room temperature overnight, then solvent was removed in vacuo and the residue partitioned between water and saturated aqueous NH4Cl. The organic phase was separated, dried (MgSO4), filtered and concentrated to give the title compound (1.8 g), used without further purification. Analytical data were consistent with those reported in Preparation 61.

1. customsolvent was removed in vacuo
2. customthe residue partitioned between water and saturated aqueous NH4Cl
3. customThe organic phase was separated
4. dry with materialdried (MgSO4)
5. filtrationfiltered
6. concentrationconcentrated