Hydrochloric Acid → 6-Ethanesulfonyl-3,3-dimethyl-2,3-dihydro-1H-indole

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Reaction Conditions

Reaction Steps

1-(6-Ethanesulfonyl-3,3-dimethyl-2,3-dihydro-indol-1-yl)-ethanone (130 mg, 0.46 mmol) was dissolved in MeOH (7 mL) and 5 M hydrochloric acid (920 μL, 4.6 mmol) was added. The solution was stirred at 90° C. for 1.5 h then solvent was removed in vacuo. The residue was quenched with saturated aqueous NaHCO3 and the product extracted with EtOAc. The organic phase was dried (MgSO4), filtered and concentrated to give the title compound (60 mg), used without further purification. MS: [M+H]+=240.

Provenance & Evidence