1-Chloro-3-iodopropane → HCID 86723955, compound

HRID 1475337Notes

Reaction equation

HRID 1475337 reaction equation
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([F:17])=[C:10]([S:13](Cl)(=[O:15])=[O:14])[CH:11]=2)[C:6]([CH3:19])([CH3:18])[CH2:5]1)(=[O:3])[CH3:2].[Cl:20][CH2:21][CH2:22][CH2:23]I>>[Cl:20][CH2:21][CH2:22][CH2:23][S:13]([C:10]1[CH:11]=[C:12]2[C:7]([C:6]([CH3:19])([CH3:18])[CH2:5][N:4]2[C:1](=[O:3])[CH3:2])=[CH:8][C:9]=1[F:17])(=[O:15])=[O:14]

Participants

3

Reactant 2

HCID 813631-Chloro-3-iodopropaneHCID 86723952HCID 86723952, compound

Product 1

HCID 86723955HCID 86723955, compoundYield 88%

Procedure

Prepared from 1-acetyl-5-fluoro-3,3-dimethyl-2,3-dihydro-1H-indole-6-sulfonyl chloride (500 mg, 1.64 mmol) and 1-chloro-3-iodo-propane (863 μL, 8.2 mmol) following similar methods to those described in Preparation 64. The title compound (502 mg) was obtained as a pale yellow oil. 1H NMR (CDCl3): 8.72 (1H, d), 7.01 (1H, d), 3.88 (2H, s), 3.75-3.57 (2H, m), 3.57-3.35 (2H, m), 2.37-2.18 (5H, m), 1.41 (6H, s).

Workup

  1. customthose described in Preparation 64

Sources & evidence

ORD record
ord-8ea7153d3dc74a748d53bad4699b35ea
Source dataset
uspto-grants-2015_04
Patent number
US09018214B2

Reaction notes

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