Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 86723957 | HCID 86723957 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 70981368 | HCID 70981368 | 189.3% |
Reaction Steps
A mixture of 6-chloro-3,3-bis-hydroxymethyl-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester (1.9 g, 5.8 mmol), DCM (50 mL) and TFA (10 mL) was stirred at 20° C. for 5 h then evaporated in vacuo to give a semi-solid. Azeotrope with THF was performed to give the title compound (2.5 g). MS: [M+H]+=228.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09018214B2 |
|---|
| Source dataset | uspto-grants-2015_04 |
|---|
| ORD ID | ord-b4013f278be1402aa94dd0882279cc16 |
|---|
| Source note | uspto-grants-2015_04 |
|---|
