HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Acetyl-6'-benzyl-1',2'-dihydrospiro[azetidine-3,3'-indole]hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Acetyl-6'-benzyl-1',2'-dihydrospiro[azetidine-3,3'-indole]-1'-yl-carboxylic acid tert-butyl ester | HCID 86723960 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-Acetyl-6'-benzyl-1',2'-dihydrospiro[azetidine-3,3'-indole]hydrochloride | HCID 90232047 | — |
Reaction Steps
1-Acetyl-6′-benzyl-1′,2′-dihydrospiro[azetidine-3,3′-indole]-1′-yl-carboxylic acid tert-butyl ester was taken up in saturated HCl in EtOAc (5 mL). The reaction was stirred for 1 h at ambient temperature and then concentrated in vacuo. The residue was taken up in MeOH and concentrated in vacuo again to yield the title compound. MS: [M+H]+=293.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09018214B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-16860118b03344e4bd66be3ecca88145 |
| Source note | uspto-grants-2015_04 |