6-(2-fluoro-benzyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine hydrochloride → HCID 70980537, compound

HRID 1475363Notes

Reaction equation

HRID 1475363 reaction equation
[ClH:1].F[C:3]1[CH:20]=[CH:19][CH:18]=[CH:17][C:4]=1[CH2:5][C:6]1[N:11]=[CH:10][C:9]2[C:12]([CH3:16])([CH3:15])[CH2:13][NH:14][C:8]=2[CH:7]=1.[Br-].[C:22](C1C=C(C=CC=1)C[Zn+])#[N:23]>>[ClH:1].[C:22]([C:20]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[CH2:5][C:6]1[N:11]=[CH:10][C:9]2[C:12]([CH3:16])([CH3:15])[CH2:13][NH:14][C:8]=2[CH:7]=1)#[N:23]

Participants

3

Reactant 2

HCID 709804166-(2-fluoro-benzyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine hydrochlorideHCID 178509756HCID 178509756, compound

Product 1

HCID 70980537HCID 70980537, compound

Procedure

Prepared in an analogous manner to 6-(2-fluoro-benzyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine hydrochloride (Preparation 119) using 3-cyanobenzylzinc bromide instead of 2-fluorobenzylzinc chloride. MS: [M+H]+=264.

Sources & evidence

ORD record
ord-30cd6b68e8ec42fead8ce59b88d4bb4f
Source dataset
uspto-grants-2015_04
Patent number
US09018214B2

Reaction notes

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