Dimethylamine → HCID 86723992, compound

HRID 1475377Notes

Reaction equation

[CH3:1][NH:2][CH3:3].[C:4]([O:8][C:9]([N:11]1[CH2:16][CH2:15][N:14]([CH2:17][C:18]([N:20]2[C:28]3[C:23](=[CH:24][CH:25]=[C:26]([C:29](O)=[O:30])[CH:27]=3)[CH2:22][CH2:21]2)=[O:19])[CH2:13][C@H:12]1[CH3:32])=[O:10])([CH3:7])([CH3:6])[CH3:5]>>[C:4]([O:8][C:9]([N:11]1[CH2:16][CH2:15][N:14]([CH2:17][C:18]([N:20]2[C:28]3[C:23](=[CH:24][CH:25]=[C:26]([C:29](=[O:30])[N:2]([CH3:3])[CH3:1])[CH:27]=3)[CH2:22][CH2:21]2)=[O:19])[CH2:13][C@H:12]1[CH3:32])=[O:10])([CH3:7])([CH3:5])[CH3:6]

Participants

Reactant 2

HCID 674Dimethylamine

HCID 86723991HCID 86723991, compound

Product 1

HCID 86723992HCID 86723992, compound

Procedure

Starting with dimethylamine and 1-[2-((R)-4-tert-butoxycarbonyl-3-methyl-piperazin-1-yl)-acetyl]-2,3-dihydro-1H-indole-6-carboxylic acid, the title compound was prepared by using similar methods to those described in General Procedure 1. MS: [M+H]+=431.

Sources & evidence

ORD record: ord-078ed7def6a6445db541fcbd37fd8cf0
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09018214B2

Reaction notes

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