N-methoxy-N,3-dimethylbutanamide → 6-(1,1-Difluoro-3-methyl-butyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine

HRID 1475438Notes

Reaction equation

HRID 1475438 reaction equation
[CH3:1]ON(C)C(=O)CC(C)C.[F:11][C:12]([C:17]1[CH:18]=[C:19]2[NH:25][CH2:24][C:23]([CH3:27])([CH3:26])[C:20]2=[N:21][CH:22]=1)([F:16])[CH2:13][CH2:14][CH3:15]>>[F:11][C:12]([C:17]1[CH:18]=[C:19]2[NH:25][CH2:24][C:23]([CH3:26])([CH3:27])[C:20]2=[N:21][CH:22]=1)([F:16])[CH2:13][CH:14]([CH3:1])[CH3:15]

Participants

3

Reactant 2

HCID 10975620N-methoxy-N,3-dimethylbutanamideHCID 709805096-(1,1-difluoro-butyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine

Product 1

HCID 709803276-(1,1-Difluoro-3-methyl-butyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine

Procedure

Prepared starting from N-Methoxy-3,N-dimethyl-butyramide in an analogous fashion to 6-(1,1-difluoro-butyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine (see Preparations 264 and 116. MS: [M+H]+=255.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-35529519f2c2435f8b861d3f411e5aa6
Source dataset
uspto-grants-2015_04
Patent number
US09018214B2

Reaction notes

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