HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoropyrrolidine → (2R,5S)-4-Benzyl-5-((R)-3-fluoro-pyrrolidin-1-ylmethyl)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoropyrrolidine | HCID 2759163 | — |
| Reactant | tert-butyl (2R,5R)-4-benzyl-5-(chloromethyl)-2-methylpiperazine-1-carboxylate | HCID 86724019 | — |
| Product | (2R,5S)-4-Benzyl-5-((R)-3-fluoro-pyrrolidin-1-ylmethyl)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester | HCID 70982183 | — |
Reaction Steps
The title compound was prepared following similar methods to those described in Preparation 352 starting from (2R,5R)-4-benzyl-5-chloromethyl-2-methyl-piperazine-1-carboxylic acid tert-butyl ester and (R)-3-fluoro-pyrrolidine. MS: [M+H]+=392.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09018214B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-637376c0a80f448c9834e8674a7aa2d3 |
| Source note | uspto-grants-2015_04 |