2-cyclopropyl-N-methoxy-N-methylacetamide → 6-(2-Cyclopropyl-acetyl)-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-b]pyridine-1-carboxylic acid tert-butyl ester

HRID 1475502Notes

Reaction equation

HRID 1475502 reaction equation
[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[N:12][CH:13]=[C:14](Br)[CH:15]=2)[C:10]([CH3:19])([CH3:18])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH:20]1([CH2:23][C:24](N(OC)C)=[O:25])[CH2:22][CH2:21]1>>[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[N:12][CH:13]=[C:14]([C:24](=[O:25])[CH2:23][CH:20]3[CH2:22][CH2:21]3)[CH:15]=2)[C:10]([CH3:19])([CH3:18])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 224737662-cyclopropyl-N-methoxy-N-methylacetamideHCID 70980192HCID 70980192, compound

Product 1

HCID 709822506-(2-Cyclopropyl-acetyl)-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-b]pyridine-1-carboxylic acid tert-butyl ester

Procedure

Prepared from 6-bromo-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-b]pyridine-1-carboxylic acid tert-butyl ester and 2-cyclopropyl-N-methoxy-N-methyl-acetamide using a procedure analogous to that of Preparation 263. MS: [M+H]+=331.

Workup

  1. customof Preparation 263

Sources & evidence

ORD record
ord-fe25786b54cf43059de5782f26e1074b
Source dataset
uspto-grants-2015_04
Patent number
US09018214B2

Reaction notes

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