反应详情

Acetic acid (30.0 mL) and Pd/C (10%, 6.0 g) were added to a solution of (2R,5S)-4-benzyl-2-methyl-5-morpholin-4-ylmethyl-piperazine-1-carboxylic acid tert-butyl ester (9.0 g, 23.1 mmol) in EtOH (240 mL) and the resulting mixture was hydrogenated at 1 bar for 3 h. The catalyst was removed by filtration and the solvent was removed in vacuo. The residue was dissolved in DCM (150 mL), the organic solution was washed with saturated aqueous NaHCO3 (150 mL), water (150 mL), dried (MgSO4) and evaporated to give the title compound as a colourless gum (6.57 g, 95%). 1H NMR (CDCl3): 4.32-3.90 (1H, m), 3.77-3.64 (5H, m), 3.30 (1H, dd), 3.16-2.82 (2H, m), 2.67 (1H, dd), 2.59-2.49 (2H, m), 2.47-2.30 (2H, m), 2.21 (1H, dd), 2.17-2.07 (2H, m), 1.47 (9H, s), 1.27 (3H, d).

1. customThe catalyst was removed by filtration
2. customthe solvent was removed in vacuo
3. dissolutionThe residue was dissolved in DCM (150 mL)
4. washthe organic solution was washed with saturated aqueous NaHCO3 (150 mL), water (150 mL)
5. dry with materialdried (MgSO4)
6. customevaporated