HCID 70981690, compound → HCID 70980962, compound

HRID 1475507Notes

Reaction equation

HRID 1475507 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][C@H:12]([CH2:14][N:15]2[CH2:19][CH2:18][C@@H:17]([F:20])[CH2:16]2)[N:11]([CH2:21][C:22]([O:24]CC2C=CC=CC=2)=[O:23])[CH2:10][C@H:9]1[CH3:32])=[O:7])([CH3:4])([CH3:3])[CH3:2]>CCO>[C:1]([O:5][C:6]([N:8]1[CH2:13][C@H:12]([CH2:14][N:15]2[CH2:19][CH2:18][C@@H:17]([F:20])[CH2:16]2)[N:11]([CH2:21][C:22]([OH:24])=[O:23])[CH2:10][C@H:9]1[CH3:32])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 70981690HCID 70981690, compound

Product 1

HCID 70980962HCID 70980962, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared from (2R,5S)-4-benzyloxycarbonylmethyl-5-((R)-3-fluoro-pyrrolidin-1-ylmethyl)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester using a similar method to that described in Preparation 272 (EtOH used as solvent). 1H NMR (CDCl3): 10.12-9.12 (1H, brs), 5.27 (1H, d), 4.17-3.89 (1H, m), 3.81-3.45 (3H, m), 3.45-2.78 (8H, m), 2.78-2.43 (2H, m), 2.42-1.99 (2H, m), 1.47 (9H, s), 1.23 (3H, d).

Sources & evidence

ORD record
ord-ebbdf7c52f5949218f3c7e8e81d1fba4
Source dataset
uspto-grants-2015_04
Patent number
US09018214B2

Reaction notes

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