HRID1475516

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID641498

(R)-3-METHYLMORPHOLINE

C5H11NO

结构：CCCC(F)(F)c1cnc2c(c1)N(C(=O)CN1C[C@@H](C)N(C(=O)OC(C)(C)C)C[C@@H]1CCl)CC2(C)C

HCID86724041

未命名化合物

PRODUCTS

生成物

结构：CCCC(F)(F)c1cnc2c(c1)N(C(=O)CN1C[C@@H](C)N(C(=O)OC(C)(C)C)C[C@@H]1CN1CCOC[C@H]1C)CC2(C)C

HCID70981092

未命名化合物

PROCEDURE

实验过程

Prepared from (2R,5R)-5-chloromethyl-4-{2-[6-(1,1-difluoro-butyl)-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-b]pyridin-1-yl]-2-oxo-ethyl}-2-methyl-piperazine-1-carboxylic acid tert-butyl ester and (R)-3-methyl-morpholine in a similar manner to General Procedure 6. MS: [M+H]+=594.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1230e1e5c77548f9bf5dc8fd3f3ab2ce
来源数据集: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09018214B2
来源说明: uspto-grants-2015_04

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:13][C@H:12]([CH2:14]Cl)[N:11]([CH2:16][C:17]([N:19]2[C:27]3[C:22](=[N:23][CH:24]=[C:25]([C:28]([F:33])([F:32])[CH2:29][CH2:30][CH3:31])[CH:26]=3)[C:21]([CH3:35])([CH3:34])[CH2:20]2)=[O:18])[CH2:10][C@H:9]1[CH3:36])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:37][C@@H:38]1[CH2:43][O:42][CH2:41][CH2:40][NH:39]1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][C@H:12]([CH2:14][N:39]2[CH2:40][CH2:41][O:42][CH2:43][C@H:38]2[CH3:37])[N:11]([CH2:16][C:17]([N:19]2[C:27]3[C:22](=[N:23][CH:24]=[C:25]([C:28]([F:33])([F:32])[CH2:29][CH2:30][CH3:31])[CH:26]=3)[C:21]([CH3:35])([CH3:34])[CH2:20]2)=[O:18])[CH2:10][C@H:9]1[CH3:36])=[O:7])([CH3:4])([CH3:3])[CH3:2]