Acetic Acid → 2-Chloro-5-fluoropyridine-3-carboxamide

HRID 147559Notes

Reaction equation

HRID 147559 reaction equation
[CH3:13][C:14](=[O:15])[OH:16].[CH3:17][OH:18].[Cl:1][c:2]1[c:3]([C:4](=[O:5])[NH2:6])[cH:7][c:8]([F:12])[c:9]([Cl:11])[n:10]1.[Zn:19]>>[Cl:1][c:2]1[c:3]([C:4](=[O:5])[NH2:6])[cH:7][c:8]([F:12])[cH:9][n:10]1

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 887MethanolHCID 23994ZincHCID 27740222,6-Dichloro-5-fluoronicotinamide

Product 1

HCID 126297962-Chloro-5-fluoropyridine-3-carboxamide

Sources & evidence

ORD record
ord-581b85a0648d4eb397c1fdf75d7b51dd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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