4-Bromostyrene → HCID 58288379, compound

Temperature

0 °C

5.0 g (27.31 mmol) of 4-bromostyrene were dissolved in 40 ml of dichloromethane, the mixture was cooled to 0° C. and 13.21 g (81.94 mmol) of triethylamine trihydrofluoride were added. 5.83 g (32.78 mmol) of N-bromosuccinimide were then added in three portions. The mixture was stirred at RT overnight. After dilution with dichloromethane, the reaction mixture was added to ice-water. The organic phase was washed successively with 1 N hydrochloric acid, water and saturated sodium bicarbonate solution, dried over magnesium sulphate and concentrated under reduced pressure. The residue was purified by chromatography on silica gel (mobile phase pentane). This gave 4.14 g (53.8% of theory) of the title compound.

1. washThe organic phase was washed successively with 1 N hydrochloric acid, water and saturated sodium bicarbonate solution
2. dry with materialdried over magnesium sulphate
3. concentrationconcentrated under reduced pressure
4. customThe residue was purified by chromatography on silica gel (mobile phase pentane)

ORD record

ord-e5fca9cc6a434cff9bf2166feed5657d

Source dataset

uspto-grants-2015_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09018258B2