Hydrochloric Acid → HCID 68006818, compound

Participants

Reaction Steps

7.55 g (27.9 mmol) of methyl (4-chloro-2-fluorophenyl)(cyclopentyl)acetate were dissolved in 32 ml each of THF, methanol and water, and 11.15 g (287.9 mmol) of sodium hydroxide were added with ice cooling. The reaction mixture was stirred at RT overnight and then diluted with water and adjusted to pH 2 with 1 N hydrochloric acid. The aqueous phase was extracted three times with ethyl acetate. The combined organic phases were dried over sodium sulphate and concentrated under reduced pressure. The solid that remained was triturated with water, filtered off with suction and dried thoroughly under reduced pressure. This gave 6.96 g of the target compound (97.2% of theory).

Provenance & Evidence