tert-Butyl 1-(3-amino-4-fluorobenzyl)cyclopropanecarboxylate → tert-Butyl 1-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluoro-benzyl)cyclopropanecarboxylate

Participants

Reaction Steps

According to General Procedure 6, 1.2 g (4.5 mmol) of (2RS,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid and 1.3 g (4.95 mmol) of tert-butyl 1-(3-amino-4-fluorobenzyl)-cyclopropanecarboxylate gave, after purification of the crude product by flash chromatography (silica gel; mobile phase cyclohexane/ethyl acetate 20:1), 1.6 g (69% of theory) of the title compound.

Provenance & Evidence