Methanol → HCID 67957891, compound

Participants

Reaction Conditions

Reaction Steps

262 mg (about 0.93 mmol) of 1-[1-(4-chloro-3-nitrophenyl)propyl]cyclopropanecarboxylic acid were dissolved in 5 ml of methanol, the mixture was cooled to 0° C. and 0.14 ml (1.85 mmol) of thionyl chloride was added dropwise. The reaction solution was then slowly warmed to room temperature and stirred at this temperature overnight. The reaction mixture was then concentrated to dryness and the residue was taken up in 10 ml of dichloromethane. The solution was washed with water, dried over magnesium sulphate and concentrated under reduced pressure. This gave 224 mg of the target compound (81% of theory).

Provenance & Evidence