Water → HCID 68006824, compound

Participants

Reaction Steps

6.60 g (14.1 mmol) of (+/−)-tert-butyl 1-(3-{[(4-chlorophenyl)(cyclopentyl)acetyl]amino}-benzyl)cyclopropanecarboxylate were dissolved in 41.8 ml of dichloromethane and, after addition of a drop of water, 10.9 ml of TFA were added at RT. The reaction mixture was stirred at RT for 1 h and then concentrated under reduced pressure. The residue was initially dried under high vacuum and then triturated with diisopropyl ether. The resulting solid was filtered off with suction and dried under high vacuum. This gave 4.52 g (77.8% of theory) of the target compound.

Provenance & Evidence