HCID 67169986, compound → HCID 67168996, compound

HRID 1475696Notes

Reaction equation

HRID 1475696 reaction equation
[CH3:1][O:2][C:3]([C:5]1([NH:16]C(OCC2C=CC=CC=2)=O)[CH2:15][CH2:14][CH2:13][C:8]2([O:12][CH2:11][CH2:10][O:9]2)[CH2:7][CH2:6]1)=[O:4].[H][H]>CO.[Pd]>[CH3:1][O:2][C:3]([C:5]1([NH2:16])[CH2:15][CH2:14][CH2:13][C:8]2([O:9][CH2:10][CH2:11][O:12]2)[CH2:7][CH2:6]1)=[O:4]

Participants

5

Reactant 2

HCID 67169986HCID 67169986, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 67168996HCID 67168996, compoundYield 76.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

66 mg of 8-benzyloxycarbonylamino-1,4-dioxa-spiro[4.6]undecane-8-carboxylic acid methyl ester was dissolved in methanol and hydrogenated in an H-cube™ hydrogenation reactor (ThalesNano, Budapest, Hungary) at a hydrogen pressure of 100 bar at 40° C. over a cartridge with 10% palladium on charcoal. The mixture was evaporated to dryness to yield the crude title compound (32 mg).

Workup

  1. customThe mixture was evaporated to dryness

Sources & evidence

ORD record
ord-1c291fe884384b7ca36defb744a8ef15
Source dataset
uspto-grants-2015_04
Patent number
US09018383B2

Reaction notes

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