HCID 53869348, compound → HCID 67170680, compound

HRID 1475720Notes

Reaction equation

HRID 1475720 reaction equation
C[O:2][C:3]([C:5]1([NH2:12])[CH2:11][CH2:10][CH:9]=[CH:8][CH2:7][CH2:6]1)=[O:4].[CH3:13][O:14][C:15]1[CH:23]=[CH:22][C:18]([C:19](O)=[O:20])=[CH:17][C:16]=1[O:24][CH2:25][CH2:26][C:27]1[CH:28]=[C:29]([CH3:33])[CH:30]=[CH:31][CH:32]=1>>[CH3:13][O:14][C:15]1[CH:23]=[CH:22][C:18]([C:19]([NH:12][C:5]2([C:3]([OH:2])=[O:4])[CH2:11][CH2:10][CH:9]=[CH:8][CH2:7][CH2:6]2)=[O:20])=[CH:17][C:16]=1[O:24][CH2:25][CH2:26][C:27]1[CH:28]=[C:29]([CH3:33])[CH:30]=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 53869348HCID 53869348, compoundHCID 67076259HCID 67076259, compound

Product 1

HCID 67170680HCID 67170680, compound

Procedure

1-Amino-cyclohept-4-enecarboxylic acid methyl ester (K. Hammer et al., Tetrahedron 53 (1997), 2309-2322) was coupled to 4-methoxy-3-(2-m-tolyl-ethoxy)-benzoic acid analogy to step 1 of example 3. The ester intermediate was hydrolyzed in analogy to step 4 of example 1 to yield the title compound.

Sources & evidence

ORD record
ord-e6c406d212ec4a378d938a8da9881fd9
Source dataset
uspto-grants-2015_04
Patent number
US09018383B2

Reaction notes

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