HCID 67076259, compound → HCID 67170945, compound

HRID 1475722Notes

Reaction equation

HRID 1475722 reaction equation
Cl.C([O:4][C:5]([C:7]1([NH2:12])[CH2:10][CH:9]([CH3:11])[CH2:8]1)=[O:6])C.[CH3:13][O:14][C:15]1[CH:23]=[CH:22][C:18]([C:19](O)=[O:20])=[CH:17][C:16]=1[O:24][CH2:25][CH2:26][C:27]1[CH:28]=[C:29]([CH3:33])[CH:30]=[CH:31][CH:32]=1>>[CH3:13][O:14][C:15]1[CH:23]=[CH:22][C:18]([C:19]([NH:12][C:7]2([C:5]([OH:4])=[O:6])[CH2:8][CH:9]([CH3:11])[CH2:10]2)=[O:20])=[CH:17][C:16]=1[O:24][CH2:25][CH2:26][C:27]1[CH:28]=[C:29]([CH3:33])[CH:30]=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 67076259HCID 67076259, compoundHCID 71741590HCID 71741590, compound

Product 1

HCID 67170945HCID 67170945, compound

Procedure

The compound of step 1 (65 mg, 0.413 mmol) was coupled to 4-methoxy-3-(2-m-tolyl-ethoxy)-benzoic acid in analogy to step 1 of example 3. The ester intermediate was hydrolyzed in analogy to step 4 of example 1 to yield the title compound as mixture of the cis isomer and the trans isomer.

Sources & evidence

ORD record
ord-c52f4f59fe5b4124ba5b38ca42ee4502
Source dataset
uspto-grants-2015_04
Patent number
US09018383B2

Reaction notes

Loading…