HCID 86672573, compound → 4-(2-Methanesulfonyl-ethyl)-3-(2-m-tolyl-ethoxy)-benzoic Acid Methyl Ester

HRID 1475803Notes

Reaction equation

HRID 1475803 reaction equation
[CH3:1][O:2][C:3](=[O:26])[C:4]1[CH:9]=[CH:8][C:7](/[CH:10]=[CH:11]/[S:12]([CH3:15])(=[O:14])=[O:13])=[C:6]([O:16][CH2:17][CH2:18][C:19]2[CH:20]=[C:21]([CH3:25])[CH:22]=[CH:23][CH:24]=2)[CH:5]=1.[H][H]>[Pd].CO>[CH3:1][O:2][C:3](=[O:26])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][S:12]([CH3:15])(=[O:14])=[O:13])=[C:6]([O:16][CH2:17][CH2:18][C:19]2[CH:20]=[C:21]([CH3:25])[CH:22]=[CH:23][CH:24]=2)[CH:5]=1

Participants

5

Reactant 2

HCID 86672573HCID 86672573, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 671694814-(2-Methanesulfonyl-ethyl)-3-(2-m-tolyl-ethoxy)-benzoic Acid Methyl EsterYield 99.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

250 mg of 4-((E)-2-Methanesulfonyl-vinyl)-3-(2-m-tolyl-ethoxy)-benzoic acid methyl ester were dissolved using 10 ml of methanol and hydrogenated under an 1.5 bar atmosphere of hydrogen using 50 mg of Pd/C (10%, 50% water) for 30 minutes. The catalyst was then removed by filtration and the solution evaporated to yield 250 mg of the title compound that was used without further purification.

Workup

  1. customThe catalyst was then removed by filtration
  2. customthe solution evaporated

Sources & evidence

ORD record
ord-d5e6544ed1e84e8e93f870acd9b345e3
Source dataset
uspto-grants-2015_04
Patent number
US09018383B2

Reaction notes

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