Aniline → HCID 68281222, compound

Participants

Reaction Steps

A reactor was charged with 401 mg (0.10 mmol) of 2,2,2-trichloroethyl 2-(3-oxo-3-phenylpropyl)phenylcarbamate (an4) obtained in Synthesis Example 8, 36.9 mg (0.10 mmol) of tetrabutylammonium iodide (Bu4N+I−), and 50 mL of ethyl acetate as a solvent to prepare a solution. Subsequently, 364 μL of 5.5 M decane solution (manufactured by Aldrich) containing 2.0 mmol of tert-butyl hydroperoxide (TBHP) as an oxidizing agent was added to the solution in an amount corresponding to 2 equivalents based on the aniline derivative (an4). After adjusting the temperature of the reaction system to room temperature (about 20° C.), the mixture was stirred for 5 hours, and then stirred (reacted) at 50° C. for 14 hours. After cooling the reaction mixture including the reaction product to room temperature, the reaction mixture was added to 20 mL of water, and extracted twice with ethyl acetate. The resulting organic layer was sequentially washed with a saturated sodium sulfite (Na2SO3) aqueous solution, an NaCl aqueous solution, and water, followed by the addition of anhydrous sodium sulfate (Na2SO4). The solvent was then evaporated under reduced pressure to obtain a concentrate including a crude product. The concentrate was subjected to silica gel flash column chromatography (eluant: hexane/ethyl acetate=6/1) to obtain 2,2,2-trichloroethyl 2-benzoylindoline-1-carboxylate (white solid) represented by the following formula (as4). The yield was 48% (see Table 1-2). The analysis data for the resulting compound (as4) is shown below.

Provenance & Evidence