Water → HCID 86711216, compound

HRID 1475932Notes

Reaction equation

HRID 1475932 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[C:9]([C:17]3[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=3)[C:10](/[CH:11]=[CH:12]/[CH:13]=[N+](C)C)=[C:4]2[CH:3]=1.C(=O)(O)[O-:26].[K+].O>CO>[Br:1][C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[C:9]([C:17]3[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=3)[C:10](/[CH:11]=[CH:12]/[CH:13]=[O:26])=[C:4]2[CH:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 516893Potassium BicarbonateHCID 136377202HCID 136377202, compound

Product 1

HCID 86711216HCID 86711216, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a stirred solution of (E)-N-(3-(5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl)allylidene)-N-methylmethanaminium (470 mg, 1.22 mmol) in methanol (5 mL) was added a 15% solution of potassium bicarbonate (5 mL) and the mixture was stirred at room temperature for 1 h. Water was added and methanol was evaporated under reduced pressure. Filtration of the precipitate afforded 322 mg of the title compound. LCMS m/z 357.0, 359.0 (M+H)+, ret. time=2.70 min.

Workup

  1. custommethanol was evaporated under reduced pressure
  2. filtrationFiltration of the precipitate

Sources & evidence

ORD record
ord-5fa716cfb3b34528a323cf4e06f911e1
Source dataset
uspto-grants-2015_04
Patent number
US09018395B2

Reaction notes

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