Triethylamine → HCID 60142300, compound

Participants

Reaction Steps

(E)-2-(4-acetylphenyl)-N,N-diisopentyl-3-(3-(piperidin-1-yl)prop-1-en-1-yl)pyrazolo[1,5-a]pyridine-5-carboxamide (80 mg, 0.15 mmol) was dissolved in MeOH (3 mL) and triethylamine (1 mL) and 10% Pd/C (40 mg) was added. The vessel was flushed with 3 cycles of vacuum then hydrogen from a balloon, and the reaction mixture was stirred for 4 h at room temperature, filtered through Celite and evaporated. The residue was purified by preparative HPLC on a reverse-phase Zorbax SB-C18 column 21.2×100 mm eluted with MeOH-water-0.1% TFA. Isocratic 30% for 3 minutes then Gradient 30% to 100% MeOH over 14 minutes. LCMS m/z 547.4 (weak) (M+H)+, 458.3 (strong). ret. time=2.35 min.

Provenance & Evidence