HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pivaloyl chloride → [(tert-Butoxy)carbonyl]amino 2,2-dimethylpropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pivaloyl chloride | HCID 62493 | — |
| Reactant | tert-butyl N-hydroxycarbamate | HCID 97534 | — |
| Product | [(tert-Butoxy)carbonyl]amino 2,2-dimethylpropanoate | HCID 300008 | — |
Reaction Steps
[(tert-Butoxy)carbonyl]amino 2,2-dimethylpropanoate is prepared from trimethyl acetyl chloride and N-tert-butoxycarbonyl hydroxylamine according to Scheme 1 described by Carpino et al. J. Am. Chem. Soc. 1959, 955-957. (6.4 g, 78%), 1H NMR (250 MHz, DMSO-d6) δ ppm 10.46 (1H, br. s.), 1.40 (9H, s), 1.20 (9H, s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09018411B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-f8f5479f001e478ebf05ea4b22f988a3 |
| Source note | uspto-grants-2015_04 |