2-Methanesulfonylbenzene-1-sulfonyl chloride → HCID 53241812, compound

HRID 1476007Notes

Reaction equation

HRID 1476007 reaction equation
[C:1]([O:5][C:6]([NH:8][O:9][C:10]([O:12][CH2:13][CH2:14][O:15][CH3:16])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:17][S:18]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[S:27](Cl)(=[O:29])=[O:28])(=[O:20])=[O:19]>>[C:1]([O:5][C:6]([N:8]([O:9][C:10]([O:12][CH2:13][CH2:14][O:15][CH3:16])=[O:11])[S:27]([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=1[S:18]([CH3:17])(=[O:20])=[O:19])(=[O:29])=[O:28])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27351782-Methanesulfonylbenzene-1-sulfonyl chlorideHCID 86654181HCID 86654181, compound

Product 1

HCID 53241812HCID 53241812, compound

Procedure

1-({[(tert-Butoxy)carbonyl]({[(2-methoxyethoxy)carbonyl]oxy})amino}-sulfonyl)-2-methanesulfonylbenzene (100) is prepared from 1-{[({[(tert-butoxy)carbonyl]amino}oxy) carbonyl]oxy}-2-methoxyethane and 2-methylsulfonyl benzenesulfonyl chloride according to Scheme 11. (0.59 g, 46%), 1H NMR (500 MHz, CHLOROFORM-d) δ ppm 8.16-8.80 (2H, m), 7.54-8.02 (2H, m), 4.47-4.47 (2H, m), 3.66 (2H, d, 4.1 Hz), 3.41 (3H, s), 3.38 (3H, s), 1.42 (9H, s)

Sources & evidence

ORD record
ord-df7718bd16204406accc034803512623
Source dataset
uspto-grants-2015_04
Patent number
US09018411B2

Reaction notes

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