2-Methanesulfonylbenzene-1-sulfonyl chloride → HCID 53241813, compound

HRID 1476008Notes

Reaction equation

HRID 1476008 reaction equation
[C:1]([O:5][C:6]([NH:8][O:9][C:10]([O:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][CH3:19])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:20][S:21]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[S:30](Cl)(=[O:32])=[O:31])(=[O:23])=[O:22]>>[C:1]([O:5][C:6]([N:8]([O:9][C:10]([O:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][CH3:19])=[O:11])[S:30]([C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=1[S:21]([CH3:20])(=[O:23])=[O:22])(=[O:32])=[O:31])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27351782-Methanesulfonylbenzene-1-sulfonyl chlorideHCID 86654182HCID 86654182, compound

Product 1

HCID 53241813HCID 53241813, compound

Procedure

1-({[(tert-Butoxy)carbonyl]({[2-(2-methoxyethoxy)ethoxy]carbonyl}oxy)-amino}sulfonyl)-2-methanesulfonylbenzene (101) is prepared from 1-(2-{[({[(tert-butoxy)carbonyl]amino}oxy)carbonyl]oxy}ethoxy)-2-methoxyethane and 2-methylsulfonyl benzene sulfonyl chloride according to Scheme 11. (2.72 g, 70%), 1H NMR (500 MHz, CHLOROFORM-d) δ ppm 8.40 (2H, ddd, 12.7, 7.5, 1.5 Hz), 7.86 (2 H, m), 4.37-4.56 (2H, m), 3.71-3.85 (2H, m), 3.62-3.71 (2H, m), 3.50-3.60 (2H, m), 3.43 (3H, s), 3.39 (3H, s), 1.43 (9H, s).

Sources & evidence

ORD record
ord-2ceb6a2a70ec439d83deba973d621f46
Source dataset
uspto-grants-2015_04
Patent number
US09018411B2

Reaction notes

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