HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosgene → 2-{[({[(tert-Butoxy)carbonyl]amino}oxy)carbonyl]oxy}-1,3-diethoxypropane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | 1,3-Diethoxy-2-propanol | HCID 77664 | — |
| Reactant | tert-butyl N-hydroxycarbamate | HCID 97534 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-{[({[(tert-Butoxy)carbonyl]amino}oxy)carbonyl]oxy}-1,3-diethoxypropane | HCID 86654183 | — |
Reaction Steps
2-{[({[(tert-Butoxy)carbonyl]amino}oxy)carbonyl]oxy}-1,3-diethoxypropane is prepared from tert-butyl N-hydroxycarbamate and 1,3-diethoxypropan-2-ol using 20% solution of phosgene in toluene according to Scheme 10. (10.37 g, 85%), 1H NMR (500 MHz, CHLOROFORM-d) δ ppm 7.73 (1H, s), 5.03 (1H, quin, 5.2 Hz), 3.64 (4H, dd, 5.1, 2.7 Hz), 3.48-3.57 (4H, m), 1.50 (9H, s), 1.19 (6H, t, 7.0 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09018411B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-96e6f0292a884a2884d4b6f9cae6d922 |
| Source note | uspto-grants-2015_04 |