HCID 58288271, compound → HCID 58288162, compound

Participants

Reaction Steps

2.50 g (4.63 mmol) of (+/−)-tert-butyl 3-[3-(benzylamino)-4-chlorophenyl]-2-cyclopropylpropanoate were dissolved in 160 ml of ethyl acetate, the mixture was deoxygenated with argon and 150 mg of palladium on carbon (10%) were added. The reaction mixture was stirred at RT under an atmosphere of hydrogen at atmospheric pressure for 8 h. The mixture was then filtered through celite, the residue was washed with ethyl acetate, the filtrate was concentrated under reduced pressure and the residue was dried under high vacuum. The residue was purified by chromatography on silica gel (mobile phase pure cyclohexane to cyclohexane/ethyl acetate 20:1). This gave 1.41 g of the target product (73.6% of theory).

Provenance & Evidence