HCID 67206429, compound → HCID 58288181, compound

Participants

Reaction Steps

3.05 g (12.7 mmol) of methyl 3-(3-amino-4-chlorophenyl)pent-3-enoate and 0.85 g (3.55 mmol) of methyl 3-(3-amino-4-chlorophenyl)pent-2-enoate were dissolved together in 500 ml of ethyl acetate, 346 mg (0.325 mmol) of palladium on carbon (10%) were added and the mixture was stirred at RT under an atmosphere of hydrogen at atmospheric pressure overnight. The reaction mixture was then filtered off through celite, the residue was washed with ethyl acetate and the filtrate was concentrated. Drying of the residue under high vacuum gave 3.73 g of the target product (94.8% of theory).

Provenance & Evidence