Hydrochloric Acid → HCID 58288333, compound

Participants

Reaction Conditions

Reaction Steps

770 mg (1.52 mmol) of ethyl {1-[4-chloro-3-(dibenzylamino)phenyl]-3,3-dimethoxycyclobutyl}-acetate were dissolved in 10 ml of THF, 2 ml of 1 M hydrochloric acid were added and the mixture was stirred at 50° C. for 1 h. The reaction solution was then diluted with 10 ml of water and 10 ml of ethyl acetate. The phases were separated, and the organic phase was then dried over magnesium sulphate, filtered and concentrated to dryness using a rotary evaporator. This gave 607 mg of the title compound (87% of theory).

Provenance & Evidence