Sodium Acetate → 6-fluoro-3-(3-fluorophenyl)-2-methyl-4H-chromen-4-one

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Reaction Steps

Intermediate 73 (24 g, 0.096 moles) was taken in a RB flask and to this acetic anhydride (230 ml) and sodium acetate (55.2 g, 0.673 moles) were added and the mixture was refluxed for 12 h. After cooling to RT, the reaction mixture was quenched by the addition of ice cold water. The solid formed was filtered and washed with water. The product was dried under vacuum to afford the title compound as brown solid (26 g, quant. yield). 1H-NMR (δ ppm, CDCl3, 400 MHz): δ 7.87(dd, J=8.2,3.0 Hz, 1H), 7.48-7.36(m,3H), 7.10-6.99(m, 3H), 2.33(s, 3H).

Provenance & Evidence