Methanesulfonyl chloride → N-[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-N-pyridin-2-ylmethyl-methanesulfonamide

HRID 14762Notes

Reaction equation

HRID 14762 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:20]=[CH:21][CH:22]=2)[CH2:11][NH:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[CH:5]=[CH:4][N:3]=1.[CH3:23][S:24](Cl)(=[O:26])=[O:25]>>[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:20]=[CH:21][CH:22]=2)[CH2:11][N:12]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[S:24]([CH3:23])(=[O:26])=[O:25])[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 86603248HCID 86603248, compound

Product 1

HCID 86603247N-[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-N-pyridin-2-ylmethyl-methanesulfonamide

Procedure

Intermediate 10 was coupled with methanesulfonyl chloride following procedure D. LC-MS showed the product had the expected M+H+ of 389.

Sources & evidence

ORD record
ord-e7378bcb3f514a97a0dc75d642d197eb
Source dataset
uspto-grants-2010_06
Patent number
US07732444B2

Reaction notes

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