HCID 58269292, compound → HCID 58269286, compound

HRID 1476208Notes

Reaction equation

HRID 1476208 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]2[N:8]([CH2:20][C:21]3[O:22][C:23]4[C:28]([C:29](=[O:37])[C:30]=3[C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)=[CH:27][CH:26]=[CH:25][CH:24]=4)[N:9]=[C:10]([C:11]3[CH:16]=[C:15]([O:17]C)[CH:14]=[C:13]([F:19])[CH:12]=3)[C:3]=12>ClCCl.B(Br)(Br)Br>[NH2:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]2[N:8]([CH2:20][C:21]3[O:22][C:23]4[C:28]([C:29](=[O:37])[C:30]=3[C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=3)=[CH:27][CH:26]=[CH:25][CH:24]=4)[N:9]=[C:10]([C:11]3[CH:16]=[C:15]([OH:17])[CH:14]=[C:13]([F:19])[CH:12]=3)[C:3]=12

Participants

4

Reactant 1

HCID 58269292HCID 58269292, compound

Product 1

HCID 58269286HCID 58269286, compoundYield 36.1%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolvent2×HCID 25134Boron tribromideSolvent

Procedure

To a solution of Example 66 (0.100 g, 0.202 mmoles) in dichloromethane (15 ml), BBr3 (1M in dichloromethane, 1.0 ml) was added at 0° C. and the reaction mixture was warmed to RT and then stirred for 12 h. The reaction mixture was quenched with 1.5N HCl solution and extracted with dichloromethane. The organic layer was dried over sodium sulphate and concentrated. The crude product was purified by column chromatography with methanol: dichloromethane to afford the title compound as yellow solid (0.035 g, 36% yield). MP: 260-262° C. 1H-NMR (δ ppm, DMSO-D6, 400 MHz): δ 10.16(s,1H), 8.22(s, 1H), 8.06(dd, J=7.9, 1.5 Hz, 1H), 7.78(m,1H), 7.50(dt, J=8.0,1.0 Hz, 1H), 7.44(d, J=8.5 Hz, 1H), 7.37-7.31(m,5H), 6.86(t, J=1.5Hz, 1H), 6.82(dt, J=7.6, 2.3 Hz, 1H), 6.65 (td, J=10.9,2.3 Hz, 1H), 5.50(s,2H). Mass: 480.02(M++1).

Workup

  1. customThe reaction mixture was quenched with 1.5N HCl solution
  2. extractionextracted with dichloromethane
  3. dry with materialThe organic layer was dried over sodium sulphate
  4. concentrationconcentrated
  5. customThe crude product was purified by column chromatography with methanol

Sources & evidence

ORD record
ord-d3db2671c1764e4eb0a9cc73119acbc3
Source dataset
uspto-grants-2015_04
Patent number
US09018375B2

Reaction notes

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