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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1476274Generated: November 1, 2026

2-(Methylamino)ethanol → 2-(tert-butyldiphenylsilyloxy)-N-methylethanamine

https://huagongshe.com/reaction/1476274

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Methylamino)ethanolHCID 8016—
Reactant2-(tert-butyldiphenylsilyloxy)-N-ethylethanamineHCID 58080159—
Product2-(tert-butyldiphenylsilyloxy)-N-methylethanamineHCID 1182315849%

Reaction Steps

The title compound (4.1 g, yield: 49%) was prepared using a procedure similar to the one described for the synthesis of INTERMEDIATE 23 utilizing 2-(methylamino)ethanol (2.0 g, 26.6 mmol) as starting material. The title product was purified by column chromatography (ISCO, 40 g silica gel column, eluting with 0→100% DCM/10% MeOH in DCM with 1% NH4OH).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09018381B2
Source datasetuspto-grants-2015_04
ORD IDord-d7adfe13a4834c30a29fc5600af89214
Source noteuspto-grants-2015_04