HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Methylamino)ethanol → N-Cbz-N-methyl-2-aminoethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Methylamino)ethanol | HCID 8016 | — |
| Reactant | Benzyl ethyl(2-hydroxyethyl)carbamate | HCID 14266447 | — |
| Product | N-Cbz-N-methyl-2-aminoethanol | HCID 13279869 | 93% |
Reaction Steps
A similar procedure to that described for INTERMEDIATE 47 utilizing 2-(methylamino)ethanol (2.3 g, 30.62 mmol) as starting material was followed, with subsequent purification by column chromatography (ISCO, silica gel column, eluting with 60→100% EtOAc/hexanes for 14 minutes) to give the title product (5.96 g, yield: 93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09018381B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-404eb978b680498aa19cacb5ca3d890e |
| Source note | uspto-grants-2015_04 |