HCID 66723718, compound → HCID 131732786, compound

HRID 1476326Notes

Reaction equation

HRID 1476326 reaction equation
[ClH:1].[Si:2]([O:19][CH2:20][C@@H:21]1[CH2:26][O:25][CH2:24][CH2:23][NH:22]1)([C:15]([CH3:18])([CH3:17])[CH3:16])([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[Si](OC[C@H]1COCCN1C(OC(C)(C)C)=O)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>>[ClH:1].[Si:2]([O:19][CH2:20][C@H:21]1[CH2:26][O:25][CH2:24][CH2:23][NH:22]1)([C:15]([CH3:16])([CH3:17])[CH3:18])([C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 66723718HCID 66723718, compound2×HCID 131732785HCID 131732785, compound

Product 1

HCID 131732786HCID 131732786, compoundYield 77%

Procedure

The title product (1.2 g, yield: 77%) was prepared using a procedure similar to the one described for the synthesis of INTERMEDIATE 103. (R)-tert-Butyl 3-((tert-butyldiphenylsilyloxy)methyl)morpholine-4-carboxylate (INTERMEDIATE 106, 2.0 g, 4.39 mmol) was used as starting material. The title product was obtained as a hydrochloride salt after evaporation of the volatiles under reduced pressure.

Sources & evidence

ORD record
ord-7c7642d6377b4b238478167b7cf7fb34
Source dataset
uspto-grants-2015_04
Patent number
US09018381B2

Reaction notes

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