Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Lithium hydroxide, monohydrate → 1-isopropyl-3-methyl-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-indazole-4-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Lithium hydroxide, monohydrate | HCID 168937 | — |
| 반응물 | Methyl 1-isopropyl-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-indazole-4-carboxylate | HCID 67467136 | — |
| 반응물 | Methyl 1-isopropyl-3-methyl-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-indazole-4-carboxylate | HCID 67467381 | — |
| 생성물 | 1-isopropyl-3-methyl-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-indazole-4-carboxylic acid | HCID 67468494 | — |
반응 단계
The title compound was prepared from methyl 1-isopropyl-3-methyl-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-indazole-4-carboxylate, 1 (50 mg, 0.14 mmol) and LiOH.H2O (20 mg, 0.43 mmol) in the same manner as described for example 80 (step b). The product was collected as an off-white solid (60 mg) and used in the next step without any further purification. LCMS (ES+) m/z: 335.15.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09018382B2 |
| 출처 데이터셋 | uspto-grants-2015_04 |
| ORD ID | ord-6ae19029ce0e4ee19553cba83c5dfad1 |
| 출처 메모 | uspto-grants-2015_04 |