HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 53246507, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 67258916 | HCID 67258916 | — |
| Reactant | 4-[(4aR,10bR)-9-ethoxy-8-methoxy-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]benzoic acid | HCID 67259092 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 53246507 | HCID 53246507 | — |
Reaction Steps
The title compound is prepared analogously as described for example 1 using 4-[(4aR,10bR)-9-ethoxy-8-methoxy-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]benzoic acid (167 mg; compound C10), 1-[(2-ethyl-1,3-oxazol-5-yl)methyl]-6-phenyl-3-(piperidin-4-yl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione hydrochloride (200 mg; compound B34), HBTU (175 mg), DIPEA (0.29 ml) and DCM (3 ml). Purification by flash column chromatography [amino phase silica gel, eluent: EtOAc/methanol, 97.5/2.5 (v/v)] and afterwards by preparative HPLC gives the title compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09018175B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-7f1590489b2f4b0aa6717c2e0020f24d |
| Source note | uspto-grants-2015_04 |