HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 67259484, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 4-[(4aR,10bR)-9-ethoxy-8-methoxy-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]benzoic acid | HCID 67259092 | — |
| Reactant | HCID 67259955 | HCID 67259955 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 67259484 | HCID 67259484 | — |
Reaction Steps
1-[(1-Methyl-1H-imidazol-2-yl)methyl]-6-phenyl-3-(piperidin-4-yl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione hydrochloride (251 mg; compound B93) is reacted with 4-[(4aR,10bR)-9-ethoxy-8-methoxy-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]benzoic acid (218 mg; compound C10) and HATU (271 mg) in DCM (7 ml) in the presence of DIPEA (0.29 ml) according to the procedure described in example 52 to afford the title compound after purification by preparative HPLC as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09018175B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-b1667109730f4ce0b38c1a8d9b8895df |
| Source note | uspto-grants-2015_04 |