Potassium Carbonate → tert-butyl 4-{1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]-2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl}piperidine-1-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	3-(Chloromethyl)-5-methyl-1,2,4-oxadiazole	HCID 302157	—
Reactant	tert-butyl 4-(2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)piperidine-1-carboxylate	HCID 67257815	—
Solvent	Dimethylformamide	HCID 6228	—
Product	tert-butyl 4-{1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]-2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl}piperidine-1-carboxylate	HCID 67258328	—

Reaction Steps

According to GP1 tert-butyl 4-(2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)piperidine-1-carboxylate (200 mg; compound B50) is reacted with 3-(chloromethyl)-5-methyl-1,2,4-oxadiazole (62 mg; compound D2) in the presence of potassium carbonate (65 mg) in DMF (5 ml). Using WU1 the title compound is obtained as a solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09018175B2
Source dataset	uspto-grants-2015_04
ORD ID	ord-07674ff8ed0d4e96b13d82054d83a46c
Source note	uspto-grants-2015_04