HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → tert-butyl 4-{1-[(5-methylisoxazol-3-yl)methyl]-2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl}piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(Chloromethyl)-5-methyl-1,2-oxazole | HCID 2735763 | — |
| Reactant | tert-butyl 4-(2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)piperidine-1-carboxylate | HCID 67257815 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | tert-butyl 4-{1-[(5-methylisoxazol-3-yl)methyl]-2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl}piperidine-1-carboxylate | HCID 67258978 | — |
Reaction Steps
According to GP1 tert-butyl 4-(2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)piperidine-1-carboxylate (750 mg; compound B50) is reacted with 3-(chloromethyl)-5-methylisoxazole (231 mg; compound D6) in the presence of potassium carbonate (242 mg) in DMF (7 ml). Using WU1 the title compound is obtained as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09018175B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-8b156250c5f14eff8703f239fc483ca1 |
| Source note | uspto-grants-2015_04 |