Potassium Carbonate → HCID 67259055, compound

Participants

Reaction Conditions

Reaction Steps

According to GP1 tert-butyl 4-(2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)piperidine-1-carboxylate (563 mg; compound B50) is reacted with 5-(chloromethyl)-3-ethyl-1,2,4-thiadiazole (226 mg; compound D20) in the presence of potassium carbonate (364 mg) in DMF (10 ml). After 3 h and additionally after 6 h at 100° C. additional 5-(chloromethyl)-3-ethyl-1,2,4-thiadiazole (214 mg and 107 mg; compound D20) in DMF (5 ml each) is added, and the mixture is stirred at 100° C. for another 5 h. Using WU2 the title compound is obtained after flash column chromatography [silica gel, eluent: cyclohexane/EtOAc, 3/1 (v/v)] as a solid.

Provenance & Evidence