Hydrochloric Acid → 1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]-6-phenyl-3-piperidin-4-ylthieno[3,2-d]pyrimidine-2,4(1H,3H)-dione hydrochloride

Participants

Reaction Steps

To a solution of tert-butyl 4-{1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]-2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl}piperidine-1-carboxylate (2.86 g; compound B2) in DCM (100 ml) is added a solution of hydrogen chloride in 1,4-dioxane (10 ml, 4.0 M). The reaction mixture is stirred for 1 d at RT. The precipitate is filtered off, washed with diethyl ether and dried in vacuo to afford the title compound as a solid.

Provenance & Evidence