Trifluoroacetic acid → HCID 67258255, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-{1-[(1-ethyl-1H-pyrazol-3-yl)methyl]-2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl}piperidine-1-carboxylate (665 mg; compound B19) in DCM (5 ml) is added trifluoroacetic acid (5 ml). The reaction mixture is stirred for 3 h at RT. All volatile materials are removed in vacuo and the residue is taken up in diethyl ether. The resulting suspension is stirred at RT, then all solids are filtered off and dried in vacuo. The procedure is repeated a second time to afford the title compound as a solid.

Provenance & Evidence